Canine ALK-1 HEK293 Overexpression Lysate MBS8117248 from MyBioSource.com

Description

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

This Canine ALK-1 overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of ALK-1 protein from the overexpression lysate was verified

Product Specs
ItemCanine ALK-1 HEK293 Overexpression Lysate
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS8117248
Format1x Sample Buffer (1x modified RIPA buffer+1x SDS loading buffer).
Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF
ApplicationsWestern Blot (WB)
Quantity0.3 mg
Molecular WeightThe recombinant canine ACVRL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 339 amino acids and has a predicted molecular mass of 37.9kDa.
The apparent molecular mass of the protein is approximately 43-47kDa in SDS-PAGE under reduci
NCBI Full Gene Nameactivin A receptor like type 1
Molecule NameALK-1
TypeOverexpression Lysate
Domain/Region/TerminusMet1-Gln119
Source/Expression SystemHEK293 Cells
Cell LineHEK293